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Mao Qian-Qian, Xu Xiao-Yu, Shang Ao, Gan Ren-You, Wu Ding-Tao, Atanasov Atanas G., Li Hua-Bin. Phytochemicals for the Prevention and Treatment of Gastric Cancer: Effects and Mechanisms. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. JAN 2 2020. DOI: 10.3390/ijms21020570

来源:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 发布时间:2020-03-30 作者:甘人友(通讯作者) 点击数:

标题: Phytochemicals for the Prevention and Treatment of Gastric Cancer: Effects and Mechanisms
作者: Mao, QQ (Mao, Qian-Qian); Xu, XY (Xu, Xiao-Yu); Shang, A (Shang, Ao); Gan, RY (Gan, Ren-You); Wu, DT (Wu, Ding-Tao); Atanasov, AG (Atanasov, Atanas G.); Li, HB (Li, Hua-Bin)
来源出版物: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  卷: 21  期: 2  文献号: 570  DOI: 10.3390/ijms21020570  出版年: JAN 2 2020  
影响因子 (2018 年): 4.183
 
摘要: Gastric cancer is the fifth most common cancer, and the third most prevalent cause of cancer-related deaths in the world. Voluminous evidence has demonstrated that phytochemicals play a critical role in the prevention and management of gastric cancer. Most epidemiological investigations indicate that the increased intake of phytochemicals could reduce the risk of gastric cancer. Experimental studies have elucidated the mechanisms of action, including inhibiting cancer cell proliferation, inducing apoptosis and autophagy, and suppressing angiogenesis as well as cancer cell metastasis. These mechanisms have also been related to the inhibition of Helicobacter pylori and the modulation of gut microbiota. In addition, the intake of phytochemicals could enhance the efficacy of anticancer chemotherapeutics. Moreover, clinical studies have illustrated that phytochemicals have the potential for the prevention and the management of gastric cancer in humans. To provide an updated understanding of relationships between phytochemicals and gastric cancer, this review summarizes the effects of phytochemicals on gastric cancer, highlighting the underlying mechanisms. This review could be helpful for guiding the public in preventing gastric cancer through phytochemicals, as well as in developing functional food and drugs for the prevention and treatment of gastric cancer.
入藏号: WOS:000515380000200
PubMed ID: 31963129
语言: English
文献类型: Review
作者关键词: phytochemicals; gastric cancer; anticancer; mechanism of action
KeyWords Plus: TURMERIC CURCUMA-LONGA; CELL-CYCLE ARREST; NF-KAPPA-B; HELICOBACTER-PYLORI; IN-VITRO; DIALLYL DISULFIDE; VEGETABLE CONSUMPTION; DIETARY PATTERNS; CARCINOMA CELLS; DOWN-REGULATION
地址: [Mao, Qian-Qian; Xu, Xiao-Yu; Shang, Ao; Li, Hua-Bin] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Peoples R China.
[Gan, Ren-You] Chinese Acad Agr Sci, Inst Urban Agr, Res Ctr Plants & Human Hlth, Chengdu 610213, Peoples R China.
[Gan, Ren-You] Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China.
[Wu, Ding-Tao] Sichuan Agr Univ, Coll Food Sci, Inst Food Proc & Safety, Yaan 625014, Peoples R China.
[Atanasov, Atanas G.] Polish Acad Sci, Inst Genet & Anim Breeding, Dept Mol Biol, PL-05552 Jastrzebiec, Magdalenka, Poland.
[Atanasov, Atanas G.] Bulgarian Acad Sci, Inst Neurobiol, 23 Acad G Bonchev Str, BU-1113 Sofia, Bulgaria.
[Atanasov, Atanas G.] Univ Vienna, Dept Pharmacognosy, A-1090 Vienna, Austria.
[Atanasov, Atanas G.] Med Univ Vienna, Ludwig Boltzmann Inst Digital Hlth & Patient Safe, Spitalgasse 23, A-1090 Vienna, Austria.
通讯作者地址: Li, HB (通讯作者),Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Peoples R China.
Gan, RY (通讯作者),Chinese Acad Agr Sci, Inst Urban Agr, Res Ctr Plants & Human Hlth, Chengdu 610213, Peoples R China.
Gan, RY (通讯作者),Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China.
电子邮件地址: maoqq@mail2.sysu.edu.cn; xuxy53@mail2.sysu.edu.cn; shangao@mail2.sysu.edu.cn; ganrenyou@caas.cn; DT_Wu@sicau.edu.cn; atanas.atanasov@univie.ac.at; lihuabin@mail.sysu.edu.cn
作者识别号:
作者 Web of Science ResearcherID ORCID 号
Gan, Ren-You    0000-0002-4162-1511 
Li, Hua-Bin    0000-0003-2332-8554 
Atanasov, Atanas  C-5535-2013  0000-0003-2545-0967 
Wu, Dingtao    0000-0002-7896-1886 
出版商: MDPI
出版商地址: ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
Web of Science 类别: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
研究方向: Biochemistry & Molecular Biology; Chemistry
IDS 号: KO2KZ
eISSN: 1422-0067
29 字符的来源出版物名称缩写: INT J MOL SCI
ISO 来源出版物缩写: Int. J. Mol. Sci.
来源出版物页码计数: 26
基金资助致谢:
基金资助机构 授权号
National Key R&D Program of China 
2018YFC1604405 
Central Public-interest Scientific Institution Basal Research Fund 
Y2020XK05 
Shanghai Pujiang Talent Plan 
18PJ1404600 
Agri-X Interdisciplinary Fund of Shanghai Jiao Tong University 
Agri-X2017004 
Key Project of the Guangdong Provincial Science and Technology Program 
2014B020205002 

This research was funded by the National Key R&D Program of China (2018YFC1604405), Central Public-interest Scientific Institution Basal Research Fund (Y2020XK05), the Shanghai Pujiang Talent Plan (18PJ1404600), the Agri-X Interdisciplinary Fund of Shanghai Jiao Tong University (Agri-X2017004), and the Key Project of the Guangdong Provincial Science and Technology Program (2014B020205002).

开放获取: DOAJ Gold, Green Published

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