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Kim Gowoon, Gan Ren-You, Zhang Dan, Farha Arakkaveettil Kabeer, Habimana Olivier, Mavumengwana Vuyo, Li Hua-Bin, Wang Xiao-Hong, Corke Harold. Large-Scale Screening of 239 Traditional Chinese Medicinal Plant Extracts for Their Antibacterial Activities against Multidrug-Resistant

来源:PATHOGENS 发布时间:2020-05-02 作者:甘人友(通讯作者) 点击数:

标题: Large-Scale Screening of 239 Traditional Chinese Medicinal Plant Extracts for Their Antibacterial Activities against Multidrug-Resistant Staphylococcus aureus and Cytotoxic Activities
作者: Kim, G (Kim, Gowoon); Gan, RY (Gan, Ren-You); Zhang, D (Zhang, Dan); Farha, AK (Farha, Arakkaveettil Kabeer); Habimana, O (Habimana, Olivier); Mavumengwana, V (Mavumengwana, Vuyo); Li, HB (Li, Hua-Bin); Wang, XH (Wang, Xiao-Hong); Corke, H (Corke, Harold)
来源出版物: PATHOGENS  卷: 9  期: 3  文献号: 185  DOI: 10.3390/pathogens9030185  出版年: MAR 2020  
影响因子 (2018 年): 3.405
引用的参考文献数: 82
摘要: Novel alternative antibacterial compounds have been persistently explored from plants as natural sources to overcome antibiotic resistance leading to serious foodborne bacterial illnesses. In this study, the ethanolic extracts from 239 traditional Chinese medicinal plants (TCMP)' materials were screened to discover promising candidates that have strong antibacterial properties against multidrug-resistant Staphylococcus (S.) aureus and low cytotoxicity. The results revealed that 74 extracts exhibited good antibacterial activities (diameter of inhibition zone (DIZ) >= 15 mm). Furthermore, 18 extracts (DIZ >= 20 mm) were determined their minimum inhibitory concentrations (MIC) and minimum bactericide concentrations (MBC), ranging from 0.1 to 12.5 mg/mL and 0.78 to 25 mg/mL, respectively. In addition, most of the 18 extracts showed relatively low cytotoxicity (a median lethal concentration (LC50) >100 mu g/mL). The 18 extracts were further determined to estimate possible correlation of their phenolic contents with antibacterial activity, and the results did not show any significant correlation. In conclusion, this study selected out some promising antibacterial TCMP extracts with low cytotoxicity, including Rhus chinensis Mill., Ilex rotunda Thunb., Leontice kiangnanensis P.L.Chiu, Oroxylum indicum Vent., Isatis tinctorial L., Terminalia chebula Retz., Acacia catechu (L.f.) Willd., Spatholobus suberectus Dunn, Rabdosia rubescens (Hemsl.) H.Hara, Salvia miltiorrhiza Bunge, Fraxinus fallax Lingelsh, Coptis chinensis Franch., Agrimonia Pilosa Ledeb., and Phellodendron chinense C.K.Schneid.
入藏号: WOS:000524306100017
PubMed ID: 32143422
语言: English
文献类型: Article
作者关键词: medicinal plant; antimicrobial activity; drug resistance; foodborne pathogens; cytotoxicity; polyphenols
KeyWords Plus: ANTIBIOTIC-RESISTANCE; PHENOLIC-COMPOUNDS; NATURAL-PRODUCTS; ANTIMICROBIAL ACTIVITIES; ESSENTIAL OILS; ANTIOXIDANT; L.; POLYPHENOLS; MECHANISMS; SOLVENT
地址: [Kim, Gowoon; Gan, Ren-You; Zhang, Dan; Farha, Arakkaveettil Kabeer; Corke, Harold] Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China.
[Gan, Ren-You] Chinese Acad Agr Sci, Res Ctr Plants & Human Hlth, Inst Urban Agr, Chengdu 610213, Peoples R China.
[Habimana, Olivier] Univ Hong Kong, Sch Biol Sci, Hong Kong 999077, Peoples R China.
[Mavumengwana, Vuyo] Stellenbosch Univ, Fac Med & Hlth Sci, DST NRF Ctr Excellence Biomed TB Res, US SAMRC Ctr TB Res,Div Mol Biol & Human Genet,De, ZA-8000 Cape Town, South Africa.
[Li, Hua-Bin] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Peoples R China.
[Wang, Xiao-Hong] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China.
通讯作者地址: Gan, RY; Corke, H (通讯作者),Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China.
Gan, RY (通讯作者),Chinese Acad Agr Sci, Res Ctr Plants & Human Hlth, Inst Urban Agr, Chengdu 610213, Peoples R China.
电子邮件地址: gowoon_kim@sjtu.edu.cn; ganrenyou@caas.cn; zhang.dan@sjtu.edu.cn; farhatintu@sjtu.edu.cn; ohabim@hku.hk; vuyom@sun.ac.za; lihuabin@mail.sysu.edu.cn; wxh@mail.hzau.edu.cn; hcorke@sjtu.edu.cn
作者识别号:
作者 Web of Science ResearcherID ORCID 号
Mavumengwana, Vuyo    0000-0003-4672-6176 
Habimana, Olivier    0000-0002-6357-4285 
Gan, Ren-You    0000-0002-4162-1511 
出版商: MDPI
出版商地址: ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
Web of Science 类别: Microbiology
研究方向: Microbiology
IDS 号: LB0CL
eISSN: 2076-0817
29 字符的来源出版物名称缩写: PATHOGENS
ISO 来源出版物缩写: Pathogens
来源出版物页码计数: 19
基金资助致谢:
基金资助机构 授权号
National Key R&D Program of China 
2017YFC1600100 
China Central Public-interest Scientific Institution Basal Research Fund 
Y2020XK05 
Shanghai Pujiang Talent Plan 
18PJ1404600 
Agri-X Interdisciplinary Fund of Shanghai Jiao Tong University 
Agri-X2017004 

This research was funded by the National Key R&D Program of China (2017YFC1600100), China Central Public-interest Scientific Institution Basal Research Fund (Y2020XK05), the Shanghai Pujiang Talent Plan (18PJ1404600), and the Agri-X Interdisciplinary Fund of Shanghai Jiao Tong University (Agri-X2017004).

开放获取: DOAJ Gold

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