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Cao Shi-Yu, Zhao Cai-Ning, Xu Xiao-Yu, Tang Guo-Yi, Corke Harold, Gan Ren-You, Li Hua-Bin. Dietary plants, gut microbiota, and obesity: Effects and mechanisms. OCT 2019. DOI: 10.1016/j.tifs.2019.08.004
来源：TRENDS IN FOOD SCIENCE & TECHNOLOGY
发布时间：2019-10-16
作者：甘人友
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| 作者: Cao, SY (Cao, Shi-Yu); Zhao, CN (Zhao, Cai-Ning); Xu, XY (Xu, Xiao-Yu); Tang, GY (Tang, Guo-Yi); Corke, H (Corke, Harold); Gan, RY (Gan, Ren-You); Li, HB (Li, Hua-Bin) | ||||||||||||||||
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| 影响因子 (2018 年): 8.519 | ||||||||||||||||
| 摘要: Background: Obesity is a leading contributor to numerous diseases, such as diabetes mellitus, cardiovascular diseases, and cancers. Therefore, seeking effective and safe approaches to control obesity is essential. Gut microbiota has been demonstrated to play a critical role in the occurrence of obesity via the regulation of energy metabolism. The composition and abundance of gut microbiota can be altered by the diet. Recently, many dietary plants have been demonstrated to exert anti-obesity effects through bioactive components that modulate gut microbiota, which has drawn increasing research attention. Scope and approach: In this review, the obesity-associated gut microbiota has been summarized and classified into obesogenic and anti-obesity categories. Subsequently, some anti-obesity dietary plants with gut microbiota-modulating activities and the mechanisms of action of their bioactive components are discussed. Key findings and conclusions: The effects of gut microbiota on obesity have been found in most animal and some human studies. Certain strains of Finnicutes, Lactobacinuc, and Bacteroidetes are positively associated with obesity development, while Bifidobacterium, most Lactobacillus, and some Bacteroidetes show anti-obesity activities. Some dietary plants, such as grapes, berries, apple, turmeric, chili, soy, sorghum, and barley, show anti-obesity efficacy through increasing the diversity of gut microbiota, up-regulating anti-obesity gut microbiota and down-regulating obesogenic gut microbiota. This review may stimulate further development of functional foods to treat obesity through modulating gut microbiota. Future work will rely on the exploration of more dietary plants and their components with anti-obesity and gut microbiota-modulating effects, and further investigation of related mechanisms as well as clinical trials. |
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| 语言: English | ||||||||||||||||
| 文献类型: Review | ||||||||||||||||
| 作者关键词: Obesity; Anti-Obesity; Gut microbiota; Fruit; Vegetable; Spice | ||||||||||||||||
| KeyWords Plus: HIGH-FAT-DIET; GREEN TEA; WEIGHT-GAIN; FECAL MICROBIOTA; LIPOPOLYSACCHARIDE PRODUCTION; GLUCOSE-INTOLERANCE; INSULIN-RESISTANCE; ADIPOSE-TISSUE; HUMAN HEALTH; BODY-WEIGHT | ||||||||||||||||
| 地址: [Cao, Shi-Yu; Zhao, Cai-Ning; Xu, Xiao-Yu; Tang, Guo-Yi; Li, Hua-Bin] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China. [Corke, Harold; Gan, Ren-You] Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China. [Gan, Ren-You] Chinese Acad Agr Sci, Inst Urban Agr, Chengdu 610213, Sichuan, Peoples R China. |
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| 通讯作者地址: Li, HB (通讯作者)，Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China. | ||||||||||||||||
| 电子邮件地址: caoshy3@mail2.sysu.edu.cn; zhaocn@mail2.sysu.edu.cn; xuxy53@mail2.sysu.edu.cn; tanggy5@mail2.sysu.edu.cn; hcorke@sjtu.edu.cn; ganrenyou@caas.cn; lihuabin@mail.sysu.edu.cn | ||||||||||||||||
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| Web of Science 类别: Food Science & Technology | ||||||||||||||||
| 研究方向: Food Science & Technology | ||||||||||||||||
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This study was supported by the National Key R&D Program of China [No. 2018YFC1604400], Technology Innovation Program of Chinese Academy of Agricultural Sciences (ASTIP), Shanghai Basic and Key Program [No. 18JC1410800], Startup Fund for Youngman Research at SJTU (SFYR at SJTU), the Agri-X Interdisciplinary Fund of Shanghai Jiao Tong University [No. Agri-X2017004], the National Natural Science Foundation of China [No. 81372976], and the Key Project of Guangdong Provincial Science and Technology Program [No. 2014B020205002]. |