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Mao Qian-Qian, Xu Xiao-Yu, Shang Ao, Gan Ren-You, Wu Ding-Tao, Atanasov Atanas G., Li Hua-Bin. Phytochemicals for the Prevention and Treatment of Gastric Cancer: Effects and Mechanisms. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. JAN 2 2020. DOI: 10.3390/ijms21020570
来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
发布时间：2020-03-30
作者：甘人友(通讯作者)
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| 作者: Mao, QQ (Mao, Qian-Qian); Xu, XY (Xu, Xiao-Yu); Shang, A (Shang, Ao); Gan, RY (Gan, Ren-You); Wu, DT (Wu, Ding-Tao); Atanasov, AG (Atanasov, Atanas G.); Li, HB (Li, Hua-Bin) | |||||||||||||||
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| 影响因子 (2018 年): 4.183 | |||||||||||||||
| 摘要: Gastric cancer is the fifth most common cancer, and the third most prevalent cause of cancer-related deaths in the world. Voluminous evidence has demonstrated that phytochemicals play a critical role in the prevention and management of gastric cancer. Most epidemiological investigations indicate that the increased intake of phytochemicals could reduce the risk of gastric cancer. Experimental studies have elucidated the mechanisms of action, including inhibiting cancer cell proliferation, inducing apoptosis and autophagy, and suppressing angiogenesis as well as cancer cell metastasis. These mechanisms have also been related to the inhibition of Helicobacter pylori and the modulation of gut microbiota. In addition, the intake of phytochemicals could enhance the efficacy of anticancer chemotherapeutics. Moreover, clinical studies have illustrated that phytochemicals have the potential for the prevention and the management of gastric cancer in humans. To provide an updated understanding of relationships between phytochemicals and gastric cancer, this review summarizes the effects of phytochemicals on gastric cancer, highlighting the underlying mechanisms. This review could be helpful for guiding the public in preventing gastric cancer through phytochemicals, as well as in developing functional food and drugs for the prevention and treatment of gastric cancer. | |||||||||||||||
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| 语言: English | |||||||||||||||
| 文献类型: Review | |||||||||||||||
| 作者关键词: phytochemicals; gastric cancer; anticancer; mechanism of action | |||||||||||||||
| KeyWords Plus: TURMERIC CURCUMA-LONGA; CELL-CYCLE ARREST; NF-KAPPA-B; HELICOBACTER-PYLORI; IN-VITRO; DIALLYL DISULFIDE; VEGETABLE CONSUMPTION; DIETARY PATTERNS; CARCINOMA CELLS; DOWN-REGULATION | |||||||||||||||
| 地址: [Mao, Qian-Qian; Xu, Xiao-Yu; Shang, Ao; Li, Hua-Bin] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Peoples R China. [Gan, Ren-You] Chinese Acad Agr Sci, Inst Urban Agr, Res Ctr Plants & Human Hlth, Chengdu 610213, Peoples R China. [Gan, Ren-You] Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China. [Wu, Ding-Tao] Sichuan Agr Univ, Coll Food Sci, Inst Food Proc & Safety, Yaan 625014, Peoples R China. [Atanasov, Atanas G.] Polish Acad Sci, Inst Genet & Anim Breeding, Dept Mol Biol, PL-05552 Jastrzebiec, Magdalenka, Poland. [Atanasov, Atanas G.] Bulgarian Acad Sci, Inst Neurobiol, 23 Acad G Bonchev Str, BU-1113 Sofia, Bulgaria. [Atanasov, Atanas G.] Univ Vienna, Dept Pharmacognosy, A-1090 Vienna, Austria. [Atanasov, Atanas G.] Med Univ Vienna, Ludwig Boltzmann Inst Digital Hlth & Patient Safe, Spitalgasse 23, A-1090 Vienna, Austria. |
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| 通讯作者地址: Li, HB (通讯作者)，Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Peoples R China. Gan, RY (通讯作者)，Chinese Acad Agr Sci, Inst Urban Agr, Res Ctr Plants & Human Hlth, Chengdu 610213, Peoples R China. Gan, RY (通讯作者)，Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China. |
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| 电子邮件地址: maoqq@mail2.sysu.edu.cn; xuxy53@mail2.sysu.edu.cn; shangao@mail2.sysu.edu.cn; ganrenyou@caas.cn; DT_Wu@sicau.edu.cn; atanas.atanasov@univie.ac.at; lihuabin@mail.sysu.edu.cn | |||||||||||||||
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| Web of Science 类别: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary | |||||||||||||||
| 研究方向: Biochemistry & Molecular Biology; Chemistry | |||||||||||||||
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This research was funded by the National Key R&D Program of China (2018YFC1604405), Central Public-interest Scientific Institution Basal Research Fund (Y2020XK05), the Shanghai Pujiang Talent Plan (18PJ1404600), the Agri-X Interdisciplinary Fund of Shanghai Jiao Tong University (Agri-X2017004), and the Key Project of the Guangdong Provincial Science and Technology Program (2014B020205002). |
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