当前位置：首页>都市农业研究所>论文专利
论文专利
Kim Gowoon, Gan Ren-You, Zhang Dan, Farha Arakkaveettil Kabeer, Habimana Olivier, Mavumengwana Vuyo, Li Hua-Bin, Wang Xiao-Hong, Corke Harold. Large-Scale Screening of 239 Traditional Chinese Medicinal Plant Extracts for Their Antibacterial Activities against Multidrug-Resistant
来源：PATHOGENS
发布时间：2020-05-02
作者：甘人友（通讯作者）
点击数：
| 标题: |
||||||||||||
| 作者: Kim, G (Kim, Gowoon); Gan, RY (Gan, Ren-You); Zhang, D (Zhang, Dan); Farha, AK (Farha, Arakkaveettil Kabeer); Habimana, O (Habimana, Olivier); Mavumengwana, V (Mavumengwana, Vuyo); Li, HB (Li, Hua-Bin); Wang, XH (Wang, Xiao-Hong); Corke, H (Corke, Harold) | ||||||||||||
| 来源出版物: |
||||||||||||
| 影响因子 (2018 年): 3.405 | ||||||||||||
| 引用的参考文献数: |
||||||||||||
| 摘要: Novel alternative antibacterial compounds have been persistently explored from plants as natural sources to overcome antibiotic resistance leading to serious foodborne bacterial illnesses. In this study, the ethanolic extracts from 239 traditional Chinese medicinal plants (TCMP)' materials were screened to discover promising candidates that have strong antibacterial properties against multidrug-resistant Staphylococcus (S.) aureus and low cytotoxicity. The results revealed that 74 extracts exhibited good antibacterial activities (diameter of inhibition zone (DIZ) >= 15 mm). Furthermore, 18 extracts (DIZ >= 20 mm) were determined their minimum inhibitory concentrations (MIC) and minimum bactericide concentrations (MBC), ranging from 0.1 to 12.5 mg/mL and 0.78 to 25 mg/mL, respectively. In addition, most of the 18 extracts showed relatively low cytotoxicity (a median lethal concentration (LC50) >100 mu g/mL). The 18 extracts were further determined to estimate possible correlation of their phenolic contents with antibacterial activity, and the results did not show any significant correlation. In conclusion, this study selected out some promising antibacterial TCMP extracts with low cytotoxicity, including Rhus chinensis Mill., Ilex rotunda Thunb., Leontice kiangnanensis P.L.Chiu, Oroxylum indicum Vent., Isatis tinctorial L., Terminalia chebula Retz., Acacia catechu (L.f.) Willd., Spatholobus suberectus Dunn, Rabdosia rubescens (Hemsl.) H.Hara, Salvia miltiorrhiza Bunge, Fraxinus fallax Lingelsh, Coptis chinensis Franch., Agrimonia Pilosa Ledeb., and Phellodendron chinense C.K.Schneid. | ||||||||||||
| 入藏号: |
||||||||||||
| PubMed ID: |
||||||||||||
| 语言: English | ||||||||||||
| 文献类型: Article | ||||||||||||
| 作者关键词: medicinal plant; antimicrobial activity; drug resistance; foodborne pathogens; cytotoxicity; polyphenols | ||||||||||||
| KeyWords Plus: ANTIBIOTIC-RESISTANCE; PHENOLIC-COMPOUNDS; NATURAL-PRODUCTS; ANTIMICROBIAL ACTIVITIES; ESSENTIAL OILS; ANTIOXIDANT; L.; POLYPHENOLS; MECHANISMS; SOLVENT | ||||||||||||
| 地址: [Kim, Gowoon; Gan, Ren-You; Zhang, Dan; Farha, Arakkaveettil Kabeer; Corke, Harold] Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China. [Gan, Ren-You] Chinese Acad Agr Sci, Res Ctr Plants & Human Hlth, Inst Urban Agr, Chengdu 610213, Peoples R China. [Habimana, Olivier] Univ Hong Kong, Sch Biol Sci, Hong Kong 999077, Peoples R China. [Mavumengwana, Vuyo] Stellenbosch Univ, Fac Med & Hlth Sci, DST NRF Ctr Excellence Biomed TB Res, US SAMRC Ctr TB Res,Div Mol Biol & Human Genet,De, ZA-8000 Cape Town, South Africa. [Li, Hua-Bin] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Peoples R China. [Wang, Xiao-Hong] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China. |
||||||||||||
| 通讯作者地址: Gan, RY; Corke, H (通讯作者)，Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China. Gan, RY (通讯作者)，Chinese Acad Agr Sci, Res Ctr Plants & Human Hlth, Inst Urban Agr, Chengdu 610213, Peoples R China. |
||||||||||||
| 电子邮件地址: gowoon_kim@sjtu.edu.cn; ganrenyou@caas.cn; zhang.dan@sjtu.edu.cn; farhatintu@sjtu.edu.cn; ohabim@hku.hk; vuyom@sun.ac.za; lihuabin@mail.sysu.edu.cn; wxh@mail.hzau.edu.cn; hcorke@sjtu.edu.cn | ||||||||||||
| 作者识别号: | ||||||||||||
|
||||||||||||
| 出版商: |
||||||||||||
| 出版商地址: |
||||||||||||
| Web of Science 类别: Microbiology | ||||||||||||
| 研究方向: Microbiology | ||||||||||||
| IDS 号: |
||||||||||||
| eISSN: |
||||||||||||
| 29 字符的来源出版物名称缩写: |
||||||||||||
| ISO 来源出版物缩写: |
||||||||||||
| 来源出版物页码计数: |
||||||||||||
| 基金资助致谢: | ||||||||||||
|
||||||||||||
|
This research was funded by the National Key R&D Program of China (2017YFC1600100), China Central Public-interest Scientific Institution Basal Research Fund (Y2020XK05), the Shanghai Pujiang Talent Plan (18PJ1404600), and the Agri-X Interdisciplinary Fund of Shanghai Jiao Tong University (Agri-X2017004). |
||||||||||||
| 开放获取: |