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Zhu Tingting, Li Linxuan, Feng Li, Mo Huijuan, Ren Maozhi. Target of Rapamycin Regulates Genome Methylation Reprogramming to Control Plant Growth in Arabidopsis. FRONTIERS IN GENETICS. DOI: 10.3389/fgene.2020.00186. MAR 3 2020.

来源：FRONTIERS IN GENETICS 发布时间：2020-05-04 作者：任茂智（通讯作者），李林宣，冯丽 点击数：

标题: Target of Rapamycin Regulates Genome Methylation Reprogramming to Control Plant Growth in Arabidopsis
作者: Zhu, TT (Zhu, Tingting); Li, LX (Li, Linxuan); Feng, L (Feng, Li); Mo, HJ (Mo, Huijuan); Ren, MH (Ren, Maozhi)
来源出版物: FRONTIERS IN GENETICS  卷: 11  文献号: 186  DOI: 10.3389/fgene.2020.00186  出版年: MAR 3 2020  
影响因子 (2018 年): 3.517
引用的参考文献数: 60
摘要: DNA methylation is an indispensable epigenetic modification that dynamically regulates gene expression and genome stability during cell growth and development processes. The target of rapamycin (TOR) has emerged as a central regulator to regulate many fundamental cellular metabolic processes from protein synthesis to autophagy in all eukaryotic species. However, little is known about the functions of TOR in DNA methylation. In this study, the synergistic growth inhibition of Arabidopsis seedlings can be observed when DNA methylation inhibitor azacitidine was combined with TOR inhibitors. Global DNA methylation level was evaluated using whole-genome bisulfite sequencing (WGBS) under TOR inhibition. Hypomethylation level of whole genome DNA was observed in AZD-8055 (AZD), rapamycin (RAP) and AZD + RAP treated Arabidopsis seedlings. Based on functional annotation and KEGG pathway analysis of differentially methylated genes (DMGs), most of DMGs were enriched in carbon metabolism, biosynthesis of amino acids and other metabolic processes. Importantly, the suppression of TOR caused the change in DNA methylation of the genes associated with plant hormone signal transduction, indicating that TOR played an important role in modulating phytohormone signals in Arabidopsis. These observations are expected to shed light on the novel functions of TOR in DNA methylation and provide some new insights into how TOR regulates genome DNA methylation to control plant growth.
入藏号: WOS:000524702400001
PubMed ID: 32194640
语言: English
文献类型: Article
作者关键词: target of rapamycin; DNA methylation; AZD-8055; rapamycin; plant growth; Arabidopsis
KeyWords Plus: DNA METHYLATION; RNA EXPRESSION; KINASE; TOR; METABOLISM; 5-AZACYTIDINE; ACCUMULATION; INHIBITORS; BALANCE; FKBP12
地址: [Zhu, Tingting; Li, Linxuan; Feng, Li; Ren, Maozhi] Chinese Acad Agr Sci, Inst Urban Agr, Chengdu, Peoples R China.
[Zhu, Tingting] Chongqing Univ, Sch Life Sci, Chongqing, Peoples R China.
[Feng, Li; Mo, Huijuan; Ren, Maozhi] Zhengzhou Univ, State Key Lab Cotton Biol, Zhengzhou Res Base, Zhengzhou, Peoples R China.
通讯作者地址: Ren, MH (通讯作者)，Chinese Acad Agr Sci, Inst Urban Agr, Chengdu, Peoples R China.
Ren, MH (通讯作者)，Zhengzhou Univ, State Key Lab Cotton Biol, Zhengzhou Res Base, Zhengzhou, Peoples R China.
电子邮件地址: renmaozhi01@caas.cn
出版商: FRONTIERS MEDIA SA
出版商地址: AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
Web of Science 类别: Genetics & Heredity
研究方向: Genetics & Heredity
IDS 号: LB5UZ
eISSN: 1664-8021
29 字符的来源出版物名称缩写: FRONT GENET
ISO 来源出版物缩写: Front. Genet.
来源出版物页码计数: 15
基金资助致谢:
基金资助机构 授权号
National Natural Science Foundation of China 
U1804231 
31972469 
Genetically Modified Organisms Breeding Major Project of China 
2019ZX08010004004 
Central Public-interest Scientific Institution Basal Research Fund 
Y2020XK04 
Chengdu Agricultural Science and Technology Center 
NASC2019TI13 

This work was supported by grants from the National Natural Science Foundation of China (Nos. U1804231 and 31972469), the Genetically Modified Organisms Breeding Major Project of China (No. 2019ZX08010004004), Central Public-interest Scientific Institution Basal Research Fund (No. Y2020XK04), and Chengdu Agricultural Science and Technology Center local financial special fund project (NASC2019TI13).
开放获取: DOAJ Gold, Green Published

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