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Zhang Shumin, Zhang Meiquan, Khalid A. Rehman, Li Linxuan, Chen Yang, Dong Pan, Wang Hanyan, Ren Maozhi. Ethylicin Prevents Potato Late Blight by Disrupting Protein Biosynthesis of Phytophthora infestans. PATHOGENS. DOI: 10.3390/pathogens9040299. APR 2020.

来源：PATHOGENS 发布时间：2020-08-05 作者：任茂智（通讯作者） 李林宣 点击数：

标题: Ethylicin Prevents Potato Late Blight by Disrupting Protein Biosynthesis of Phytophthora infestans
作者: Zhang, SM (Zhang, Shumin); Zhang, MQ (Zhang, Meiquan); Khalid, AR (Khalid, A. Rehman); Li, LX (Li, Linxuan); Chen, Y (Chen, Yang); Dong, P (Dong, Pan); Wang, HY (Wang, Hanyan); Ren, MZ (Ren, Maozhi)
来源出版物: PATHOGENS  卷: 9  期: 4  文献号: 299  DOI: 10.3390/pathogens9040299  出版年: APR 2020  
影响因子 (2019 年): 3.018
摘要: Phytophthora infestans, the causal agent of potato late blight, triggered the devastating Great Irish Famine that lasted from 1845 to 1852. Today, it is still the greatest threat to the potato yield. Ethylicin is a broad-spectrum biomimetic-fungicide. However, its application in the control of Phytophthora infestans is still unknown. In this study, we investigated the effects of ethylicin on Phytophthora infestans. We found that ethylicin inhibited the mycelial growth, sporulation capacity, spore germination and virulence of Phytophthora infestans. Furthermore, the integrated analysis of proteomics and metabolomics indicates that ethylicin may inhibit peptide or protein biosynthesis by suppressing both the ribosomal function and amino acid metabolism, causing an inhibitory effect on Phytophthora infestans. These observations indicate that ethylicin may be an anti-oomycete agent that can be used to control Phytophthora infestans.
入藏号: WOS:000534051600025
PubMed ID: 32325810
语言: English
文献类型: Article
作者关键词: Phytophthora infestans; ethylicin; potato late blight; proteomics; ribosome; metabonomics; protein biosynthesis
KeyWords Plus: SACCHAROMYCES-CEREVISIAE; KASUGAMYCIN; GROWTH; STREPTOMYCIN; INHIBITION; INITIATION; MECHANISM; BINDING
地址: [Zhang, Shumin; Zhang, Meiquan; Dong, Pan; Ren, Maozhi] Chongqing Univ, Sch Life Sci, Chongqing 401331, Peoples R China.
[Zhang, Shumin; Wang, Hanyan] North Sichuan Med Coll, Sch Basic Med Sci, Nanchong 637000, Peoples R China.
[Khalid, A. Rehman] Univ Poonch Rawalakot AJK, Dept Plant Pathol, Rawalakot 12350, Ajk, Pakistan.
[Li, Linxuan; Ren, Maozhi] Chinese Acad Agr Sci, Inst Urban Agr, Chengdu 610000, Peoples R China.
[Chen, Yang] Chinese Acad Sci, Res Ctr Atmospher Environm, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China.
通讯作者地址: Ren, MZ (corresponding author)，Chongqing Univ, Sch Life Sci, Chongqing 401331, Peoples R China.
Ren, MZ (corresponding author)，Chinese Acad Agr Sci, Inst Urban Agr, Chengdu 610000, Peoples R China.
电子邮件地址: zhangshumin@nsmc.edu.cn; zhangmeiquan@cqu.edu.cn; arkhalid@cqu.edu.cn; lilinxuan@caas.cn; chenyang@cigit.ac.cn; dongpan@cqu.edu.cn; wanghanyan@nsmc.edu.cn; renmaozhi01@caas.cn
出版商: MDPI
出版商地址: ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
Web of Science 类别: Microbiology
研究方向: Microbiology
IDS 号: LP1AB
eISSN: 2076-0817
29 字符的来源出版物名称缩写: PATHOGENS
ISO 来源出版物缩写: Pathogens
来源出版物页码计数: 13
基金资助致谢:
基金资助机构 授权号
National Natural Science Foundation of China 
U1804231 
31972469 
31672206 
Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences 
34-IUA-02 
North Sichuan Medical College 
CBY19-QD04 

This research was funded by National Natural Science Foundation of China (U1804231, No. 31972469 and 31672206); Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences (No. 34-IUA-02) and PhD research fund of North Sichuan Medical College (No. CBY19-QD04).
开放获取: DOAJ Gold, Green Published

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