李凯

李凯，研究员，博士生导师。中国农业科学院与法国国家食品、环境及劳动卫生署联合培养博士，2014年获博士学位。现任中国农业科学院都市农业研究所动物新型基因工程疫苗团队首席科学家，中国免疫学会青年工作委员会委员。主要从事动物疫病流行病学、致病机制与防控技术研究。主持国家自然科学基金青年项目、国家自然科学基金面上项目、黑龙江省优秀青年科学基金项目等科研项目10余项，以第一作者或通讯作者在国际学术期刊发表SCI研究论文 27篇，以主要完成人获得国家发明专利20项、国家新兽药证书2项、农业转基因安全证书1项、国家标准1项，申报国家一类新兽药证书1项。获四川省天府峨眉计划青年人才等荣誉称号。

邮箱：likai01@caas.cn

代表性论文：

1.Li K, Liu Y, Xu Z, Zhang Y, Luo D, Gao Y, Qian Y, Bao C, Liu C, Zhang Y, Qi X, Cui H, Wang Y, Gao L, Wang X. Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion. PLoS Pathog. 2019, 15(9):e1007999.

2.Gao L#, Li K#, Zhang Y, Liu Y, Liu C, Zhang Y, Gao Y, Qi X, Cui H, Wang Y, Wang X*. Inhibition of DNA-Sensing Pathway by Marek's Disease Virus VP23 Protein through Suppression of Interferon Regulatory Factor 7 Activation. J Virol. 2019, 93(4):e01934-18.

3.Liu Y, Gao L, Xu Z, Luo D, Zhang Y, Gao Y, Liu C, Zhang Y, Qi X, Cui H, Li K*, Wang X*. Marek's Disease Virus RLORF4 Inhibits Type I Interferon Production by Antagonizing NF-κB Activation. J Virol. 2019, 93(18):e01037-19.

4.Gao L, Liu R, Yang F, Li X, Liu C, Qi X, Cui H, Zhang Y, Wang S, Wang X, Gao Y, Li K*. Duck Enteritis Virus Inhibits the cGAS-STING DNA-Sensing Pathway To Evade the Innate Immune Response. J Virol. 2022, 96(24):e0157822.

5.Li K, Liu Y, Xu Z, Zhang Y, Yao Y, Nair V, Liu C, Zhang Y, Gao Y, Qi X, Cui H, Gao L, Wang X. Prevention of Avian Retrovirus Infection in Chickens Using CRISPR-Cas9 Delivered by Marek's Disease Virus. Mol Ther Nucleic Acids. 2020, 21:343-353.

6.Liu Y, Xu Z, Zhang Y, Yu M, Wang S, Gao Y, Liu C, Zhang Y, Gao L, Qi X, Cui H, Pan Q, Li K*, Wang X*. Marek's disease virus as a CRISPR/Cas9 delivery system to defend against avian leukosis virus infection in chickens. Vet Microbiol. 2020, 242:108589.

7.Li K, Yu Z, Lan X, Wang Y, Qi X, Cui H, Gao L, Wang X, Zhang Y, Gao Y, Liu C. Complete genome analysis reveals evolutionary history and temporal dynamics of Marek's disease virus. Front Microbiol. 2022, 13: 1046832.

8.Liu R, Gao L, Yang F, Li X, Liu C, Qi X, Cui H, Zhang Y, Wang S, Wang X, Gao Y, Li K*. Duck Enteritis Virus Protein Kinase US3 Inhibits DNA Sensing Signaling by Phosphorylating Interferon Regulatory Factor 7. Microbiol Spectr. 2022, 10(6):e0229922.

9.Yang F, Liu P, Li X, Liu R, Gao L, Cui H, Zhang Y, Liu C, Qi X, Pan Q, Liu A, Wang X, Gao Y*, Li K*. Recombinant Duck Enteritis Virus-Vectored Bivalent Vaccine Effectively Protects Against Duck Hepatitis A Virus Infection in Ducks. Front. Microbiol. 2021, 12:813010.

10.Li K, Liu Y, Liu C, Gao L, Gao Y, Zhang Y, Cui H, Qi X, Zhong L, Wang X. Evaluation of two strains of Marek's disease virus serotype 1 for the development of recombinant vaccines against very virulent infectious bursal disease virus. Antiviral Res. 2017, 139:153-160.

代表性专利：

1.李凯，高玉龙，王笑梅，高立. 表达3型鸭甲型肝炎病毒P1和3C基因的重组鸭瘟病毒及其构建方法和用途，ZL202111370551.3，中国，2023.

2.李凯，王笑梅，高玉龙，高立. 表达靶向REV的CRISPR/Cas9的重组马立克氏病病毒及其应用，ZL202010426220.6，中国，2022.

3.李凯，高玉龙，王笑梅，刘长军，张艳萍，崔红玉，高立，祁小乐，王永强，表达J亚群禽白血病病毒Gag和Env基因的重组鸡马立克氏病病毒疫苗株及其构建方法和应用，ZL201610147336.X，中国，2019.

4.李凯，王笑梅，刘长军，张艳萍，高玉龙，崔红玉，高立. 马立克氏病病毒感染性重组克隆系统及其构建方法和应用，ZL201510304703.8，中国，2017.