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预防兽医学
王琦
姓 名：王琦
性 别：女
职 称：研究员
最高学历：博士
联系电话：17384707872
电子邮箱：qiwang@caas.cn
联系地址：四川省成都市天府新区（双流区）科学城湖畔西路99号天府菁蓉D区B1栋2楼
招生专业：（博士/硕士）预防兽医学、兽医学
本人简历：
2014年6月博士毕业于中国农业科学院研究生院，2014年7月-2019年9月在美国华盛顿大学和北卡罗来纳大学教堂山分校进行博士后训练，主要从事病毒感染性疾病的免疫致病机制与免疫治疗。2020年10月至今担任西南重大与新发动物疫病防控科研团队首席科学家。担任Cell Host & Microbe，mBio，Journal of Virology, Aging, Frontier in Immunology，Frontier in Microbiology, Virology Journal 等期刊审稿人。多次在美国免疫学年会受邀做口头报告，并在波士顿获得美国逆转录病毒与机会性感染会议评选出的青年学者奖。
研究领域和研究方向：
动物病毒感染与免疫研究方向。
主要贡献：
在病毒致病机理及治疗性疫苗研制方面，取得了原创性成果。在Nature Immunology，Molecular Cell，Cell Host & Microbe，Journal of Clinical Investigation，mBio，Plos Pathogens等专业期刊发表多篇SCI论文。
获奖成果和荣誉称号：
四川省杰出青年科技人才、中国农业科学院院青年英才。
在研科研项目：
主持国家自然科学家基金面上项目、四川省杰青等基金。
主要论文和著作：
1. Haitao Guo*, Qi Wang*, Khader Ghneim, Li Wang, Elena Rampanelli, Elizabeth Holly-Guthrie, Liang Cheng, Carolina Garrido, David Margolis, Leigh Eller, Merlin Robb, Rafick Sekaly, Xian Chen, Lishan Su, Jenny Ting. Multi-omics analyses reveal that HIV-1 alters CD4 T cell immunometabolism to fuel virus replication. Nature Immunology , 2021 Feb. https://doi.org/10.1128/NI-A29484B. (* co-first author)
2. Wei Zhang*, Qi Wang*, Fan Yang, Zixiang Zhu, Yueyue Duan, Yang Yang, Weijun Cao, Keshan Zhang, Junwu Ma, Xiangtao Liu, Haixue Zheng. JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination. Plos Pathogens, 2021 Feb. DOI:10.1371/journal.ppat.1009366. (* co-first author)
3. Luo W, Zhang JW, Zhang W, Lin YL, Wang Q. Circulating levels of IL-2, IL-4, TNF-alpha, IFN-gamma, and Creactive protein are not associated with severity of COVID-19 symptoms. J Med Virol. 2020 Jun 10. doi: 10.1002/jmv.26156. (Corresponding Author)
4. Qi Wang, Lishan Su. Vpr enhances HIV-1 Env processing and virion infectivity in macrophages by modulating TET2-dependent IFITM3 expression. mBio . 2019, August, 10:e01344-19.
5. Lv, Lei*, Wang, Q*, Xu, Yanping*, Tsao, Li-chung*, Nakagawa, Tadashi, Guo, Haitao, Su, Lishan and Xiong, Yue. Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication.
Molecular Cell 70, 961–970, June 7, 2018. DOI: https://doi.org/10.1016/j.molcel.2018.05.007. (*co-first author)
6. Qi Wang , Natalia Reszka-Blanco, Liang Cheng, Guangming Li, Liguo Zhang and Lishan Su. p38 MAPK is critical for nuclear translocation of IRF-7 during CpG-induced type I IFN expression in human plasmacytoid dendritic cells. Journal of Immunology . May 1, 2018, 200 (1 Supplement) 109.6;
7. Wang, Q., Y. Gao, Y. Wang, L. Qin, X. Qi, Y. Qu, H. Gao, and X. Wang. 2012. A 205-nucleotide deletion in the 3' untranslated region of avian leukosis virus subgroup J, currently emergen in China, contributes to its pathogenicity. J Virol 86:12849-60.
8. Wang, Q., X. Ji, Y. Gao, X. Qi, X. Wang, Y. Wang, L. Qin, and H. Gao. 2013. Overexpression of MicroRNA gga-miR-1650 Decreases the Replication of Avian Leukosis Virus Subgroup J in Infected Cells. doi:10.1099/vir.0.054007-0.
J Gen Virol August 2013 vir.0.054007-0.
9. Wang, Q., Y. Gao, X. Ji, X. Qi, L. Qin, H. Gao, Y. Wang, and X. Wang. 2013. Differential expression of microRNAs in avian leukosis virus subgroup J-induced tumors. Vet Microbiol 162:232-8.
10. Wang, Q., X. Li, Ji, X. Y. Gao, X. Qi, L. Qin, H. Gao, Y. Wang, and X. Wang. (2014). A Recombinant Avian Leukosis Virus Subgroup J for Directly Monitoring Viral Infection and the Selection of Neutralizing Antibodies. PLoS One. 2014. 10.1371/journal.pone.0121770
11. Ji, X*., Wang, Q*, X. Li, X. Qi, Y. Wang, H. Gao, Y. Gao, and X. Wang. (2014). A 19-nucleotide insertion
in the leader sequence of avian leukosis virus subgroup j contributes to its replication in vitro but is not related to its pathogenicity in vivo. PLoS One 9:e84797. (*co-first author)
12. Ji, X*., Wang, Q*, Y. Gao, Y. Wang, L. Qin, X. Qi, H. Gao, and X. Wang. 2013. Development of a New Duplex Real-Time Polymerase Chain Reaction Assay for Detection of Dicer in G. gallus. J Microbiol Biotechnol 23:630-6. (*co-first author)
13. Bi W, Xu W, Cheng L, Xue J, Wang Q, Yu F, Xia S, et al. IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibits improved potency and in vivo half-life: Potential application in combination with broad neutralizing antibodies. PLoS Pathog 2019;15:e1008082.
14. Liang Cheng, Qi Wang, Guangming Li, Riddhima Banga, Jianping Ma, Haisheng Yu, Fumihiko Yasui, Zheng Zhang, Giuseppe Pantaleo, Matthieu Perreau, Sandra Zurawski , Gerard Zurawski, Yves Levy, Lishan Su. 2018. TLR3 agonist/CD40-targeting vaccination induces T cell response and reduces HIV-1 reservoirs. Journal of Clinical Investigation. 128, 4387-4396.
15. Guo, H. Konig, R. Deng, M. Riess, M. Mo, J. Zhang, L. Petrucelli, A. Yoh, S. M. Barefoot, B. Samo, M. Sempowski, G. D. Zhang, A. Colberg-Poley, A. M. Feng, H. Lemon, S. M. Liu, Y. Zhang, Y. Wen, H. Zhang, Z. Damania, B. Tsao, L. C. Wang, Q. Su, L. Duncan, J. A. Chanda, S. K. Ting, J. P. NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses. Cell Host Microbe , 2016. 19(4): p. 515-28.
16. Zhao, J. Cheng, L. Wang, H. Yu, H. Tu, B. Fu, Q. Li, G. Wang, Q. Sun, Y. Zhang, X. Liu, Z. Chen, W.Zhang, L. Su, L. Zhang, Z. (2018) Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway. PLoS Pathog 14: e1006819.
14. Chaobaihui Ye, Weiming Wang, Liang Cheng, Guangming Li,Michael Wen, Wang, Q, Qing Zhang, Dan Li, Paul Zhou and Lishan Su. Glycosyl-phosphatidylinositol (GPI)-anchored anti-HIV scFv efficiently protect CD4 T cells from HIV-1 infection and deletion in hu-PBL mice. J Virol 2016, doi: 10.1128/JVI.01389
17. Li, X., Zhu, H, Wang, Q., Sun, J, Wang, Y., Qi, X., Gao, H., Gao, Y., and Wang, X. Identification of a novel B-cell epitope specific for avian leukosis virus subgroup J gp85 protein. (2015) Arch Virol . Volume 160, Issue 4, pp 995–1004
18. Li X, Wang Q, Gao Y, Qi X, Wang Y, Gao H, Gao Y, Wang X. Quantitative iTRAQ LC-MS/MS proteomics reveals the proteome profiles of DF-1 cells after infection with subgroup J Avian leukosis virus. Biomed Res Int. 2015:395307. doi: 10.1155/2015/395307. Epub 2015 Jan 8.
19. Jiang, L., X. Zeng, Y. Hua, Q. Gao, Z. Fan, H. Chai, Wang, Q., X. Qi, Y. Wang, H. Gao, Y. Gao, and X. Wang. (2014). Genetic diversity and phylogenetic analysis of glycoprotein gp85 of avian leukosis virus subgroup J wild-bird isolates from Northeast China. Arch Virol 159:1821-6.
20. Jiang L, Zeng X, Hua Y, Gao Q, Fan Z, Chai H, Wang Q, Qi X, Wang Y, Gao H, Gao Y, Wang X.
First isolation of reticuloendotheliosis virus from mallards in China. Arch Virol . 2014 Jul;159(7):1821-6. doi: 10.1007/s00705-014-2004-8. Epub 2014 Feb 1
21. Gao, Q., Yun, B., Wang, Q., Jiang, L., Zhu, H., Gao, Y., Qin, L., Wang, Y., Qi, X., Gao, H., and Wang, X. (2013). Development and application of a Multiplex PCR method for the rapid differential diagnosis of subgroup A, B and J avian leucosis virus. J Clin Microbiol . 10.1128/JCM.02200-13
22. Jiang, L., X. Qi, Y. Gao, Y. Hua, K. Li, X. Deng, Wang, Q., L. Zhang, H. Chai, Y. Chen, C. Yin, H. Gao, L. Qin, Y. Wang, Y. Qu, Q. Chen, Z. Fan, and X. Wang. (2013). Molecular characterization and phylogenetic analysis of the reticuloendotheliosis virus isolated from wild birds in Northeast China. Vet Microbiol 166:68-75.
23. Wang, Y., Kang, Z., Gao, Y., Qin, L., Chen, L., Wang, Q., Li, J., Gao, H., Qi, X., Lin, H., and Wang, X. (2011). Development of loop-mediated isothermal amplification for rapid detection of avian leukosis virus subgroup A.
J Virol Methods 173(1), 31-6.
24. Pan Q, Wang J, Gao Y, Wang Q, Cui H, Liu C, Qi X, et al. Identification of chicken CAR homology as a cellular receptor for the emerging highly pathogenic fowl adenovirus 4 via unique binding mechanism. Emerg Microbes Infect 2020;9:586-596.
25. Zhang Y, Yu Z, Lan X, Zhang F, Wang Q, Li K, Pan Q, et al. A high frequency of Gallid herpesvirus-2 co-infection with Reticuloendotheliosis virusis associated with high tumor rates in Chinese chicken farms. Vet Microbiol 2019;237:108418.